Caspase-14 Expression by Epidermal Keratinocytes is Regulated by Retinoids in a Differentiation-associated Manner
نویسندگان
چکیده
منابع مشابه
Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation.
Caspases are a family of cysteine proteases involved in the effector arm of physiologic cell death [1]. In 1998, a novel caspase designated ‘‘caspase 14’’ was described in embryonic and adult tissues, especially epidermal keratinocytes [2—4]. Unlike other caspases (such as 3, 6 and 7), caspase 14 is not processed by typical death stimuli or activated during apoptosis induced by ultraviolet irra...
متن کاملTerminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.
Programmed cell death of epidermal keratinocytes (KC) results in the formation of cornified cells, which constitute the outermost skin layer, the stratum corneum. Here we show by reverse transcription-polymerase chain reaction, western blot, and immunohistochemistry that epidermal KC express caspase-14, a member of the caspase family of pro-apoptotic proteases, in a tissue-specific manner. Casp...
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The epidermis is a multilayered squamous epithelium in which dividing basal cells withdraw from the cell cycle and progressively differentiate as they are displaced toward the skin surface. Eventually, the cells lose their nucleus and other organelles to become flattened squames, which are finally shed from the surface as bags of cross-linked keratin filaments enclosed in a cornified envelope [...
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Objective(s):Several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. However, the precise regulation mechanism is still not clear. This study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (NHEKs) and to explore the...
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Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, exerts chemopreventive effects by selectively inducing apoptosis in tumor cells. In contrast, EGCG accelerates terminal differentiation in normal human epidermal keratinocytes (NHEK) mediated partially by up-regulation of p57/KIP2, a cyclin-dependent kinase inhibitor that confers growth arrest and differentiation. How...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2002
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.2002.19532.x